![]() ![]() B cells from hCR2 high mice were found to display a higher baseline level of apoptosis, whether analysed ex vivo or after in vitro culture, than their B6 counterparts and this was apparently linked to both surface IgM expression by the B cells and C3 levels in the mice. ![]() We found that expression of hCR2 on the B6 lpr background resulted in a significant reduction in levels of anti-nuclear antibodies (ANA) generated as mice aged but the levels of ANA were still higher than those found in age matched C57BL/6j (B6) mice. To test this hypothesis, we examined the ability of the hCR2 to block the development of spontaneous autoimmune disease on the C57BL/6j-Fas lpr/Fas lpr (B6 lpr) background. This phenotype appears to be the result of irreversible changes in B cell signalling pathways and suggested that hCR2 expressing mice are protected from developing autoimmune disease. Our previous studies have established that mice prematurely expressing human CR2 under the control of a lambda light chain promoter (in particular the hCR2 high line) have a marked deficit in their immune response to various antigens and fail to develop collagen-induced arthritis. There are also files on Alpha, Beta, and Gamma Flights, Weapon X, Project Wide Awake, Department H, the Brotherhood, Graymalkin, Zero Tolerance, Massachussets Academy, Blackbird, the Danger Room, Legacy, Morlocks, Xavier's School, Omega Red, Cerebro, the Salem Centre, Franklin Richards, Kevin McTaggart, and Bolivar Trask.The involvement of complement receptor 2 (CR2) in B cell tolerance and autoimmune disease has been revealed over the past decade or so. Curiously, there seem to be no files for Jean Grey or Wolverine, among others. Sinister), Toad, Wolfsbane, Strong Guy, Kitty Pryde, Sauron, Forge. ![]() ![]() Cecilia Reyes, Synch, Penance, Nightcrawler, Mystique, his own Lady Deathstrike, Copycat, Deadpool, Cyclops, Dazzler, the Von Struckers, Jamie Braddock, David North, Sunfire, Boom Boom, Mimic, Dr. Closer inspection reveals that Stryker is keeping files on Pyro, Sabra, Dr. These folders listed some well-known individuals or places from the X-Men universe, including: Omega Red (Russian mutant super soldier), Muir Island (Scottish mutant research facility), Project Wideawake (Codename for the Sentinel project), Franklin Richards (son of Fantastic Four's Reed Richards and Susan Storm born a mutant), and Cerebro (mutant tracking device created by Professor Xavier and Magneto). On another screen, there were a series of folders on the computer's desktop. (at around 24 mins) On Yuriko's computer, the following files of various comics characters, both famous and obscure, are listed: Guthrie (2) (Paige (Husk), and Samuel (Cannonball)) Harada, Keniucho (Silver Samurai) Kane, Garrison (Weapon X) LeBeau, Remy (Gambit) Lehnsherr, Erik (Magneto) Maddicks, Artie Madrox, Jamie (Multiple Man) Xi'an Coy Mahn (Karma) Maximoff (2) (Wanda (Scarlet Witch), and Pietro (Quicksilver)) McTaggart, Kevin (Proteus) Moonstar, Danielle (Moonstar) Munroe, Ororo (Storm) McCoy, Hank (Beast) Callasantos, Maria (Feral) Cassidy (2) (Sean (Banshee), and Tom (Black Tom)) Cheney, Lila Creed, Victor (Sabretooth) DaCosta, Roberto (Sunspot) Dane, Lorna (Polaris) Drake, Bobby (Iceman) Dukes, Fred (Blob) Espinosa, Angelo (Skin) and Gibney, Kyle (Wild Child). ![]()
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